A review on oxidative stress, diabetic complications, and the roles of honey polyphenols

Visweswara Rao Pasupuleti and Chandra Sekhar Arigela and Siew, Hua Gan and Sirajudeen Kuttulebbai Nainamohamed Salam and Kumara Thevan Krishnan and Nurhanan Abdul Rahman and Mohammad Saffree Jeffree (2020) A review on oxidative stress, diabetic complications, and the roles of honey polyphenols. Oxidative medicine and Cellular Longevity. pp. 1-16. ISSN 1942-0994

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Abstract

Despite the availability of various antidiabetic drugs, diabetes mellitus (DM) remains one of the world’s most prevalent chronic diseases and is a global burden. Hyperglycaemia, a characteristic of type 2 diabetes mellitus (T2DM), substantially leads to the generation of reactive oxygen species (ROS), triggering oxidative stress as well as numerous cellular and molecular modifications such as mitochondrial dysfunction affecting normal physiological functions in the body. In mitochondrial-mediated processes, oxidative pathways play an important role, although the responsible molecular mechanisms remain unclear. The impaired mitochondrial function is evidenced by insulin insensitivity in various cell types. In addition, the roles of master antioxidant pathway nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)/antioxidant response elements (ARE) are being deciphered to explain various molecular pathways involved in diabetes. Dietary factors are known to influence diabetes, and many natural dietary factors have been studied to improve diabetes. Honey is primarily rich in carbohydrates and is also abundant in flavonoids and phenolic acids; thus, it is a promising therapeutic antioxidant for various disorders. Various research has indicated that honey has strong wound-healing properties and has antibacterial, anti-inflammatory, antifungal, and antiviral effects; thus, it is a promising antidiabetic agent. The potential antidiabetic mechanisms of honey were proposed based on its major constituents. This review focuses on the various prospects of using honey as an antidiabetic agent and the potential insights.

Item Type:	Article
Keyword:	Oxidative stress , Diabetic , Honey
Subjects:	Q Science > QP Physiology R Medicine > RE Ophthalmology
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	DG MASNIAH AHMAD -
Date Deposited:	30 Apr 2021 08:49
Last Modified:	30 Apr 2021 08:49
URI:	https://eprints.ums.edu.my/id/eprint/26851

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