Experience of diagnosing and managing a patient with spinal Rosai-Dorfman-Destombes disease in a tuberculosis hyperendemic region

Ming, Han Tan and Choong, Hoon Foo and May Honey Ohn and Khin Maung Ohn (2022) Experience of diagnosing and managing a patient with spinal Rosai-Dorfman-Destombes disease in a tuberculosis hyperendemic region. BMJ Case Reports, 15. pp. 1-6. ISSN 1757-790X

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URL: https://casereports.bmj.com/content/bmjcr/15/3/e24...

Abstract

Classic Rosai-Dorfman-Destombes disease (RDD) is a rare histiocytic disorder with bilateral massive painless cervical lymphadenopathy. It is a mysterious disease and there is little knowledge of its pathogenesis, clinical features, radiological findings, laboratory investigations, effective treatments and prognosis. Some of its clinical presentations may overlap with those of Mycobacterium tuberculosis infection. Just like tuberculosis infection, RDD may involve many other organs, for example, skin, kidney, bone, brain and spine. The diagnosis can easily be overlooked, especially in communities hyperendemic to tuberculosis infection. We report our experience in diagnosing and managing a patient with spinal RDD with concurrent tuberculosis infection, who was treated empirically for cervical tuberculous lymphadenitis without a conclusive laboratory finding prior to her spinal condition. In view of her acute neurological deficit, emergency spinal decompression was performed. Her intraoperative spinal samples had shown classic histopathological features of RDD. We believe the lymphadenopathy was part of the clinical presentation of RDD. She showed favourable neurological recovery throughout the follow-up.

Item Type:	Article
Keyword:	Rosai-Dorfman-Destombes , RDD , Mycobacterium tuberculosis
Subjects:	R Medicine > RD Surgery > RD1-811 Surgery > RD701-811 Orthopedic surgery
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	09 Aug 2022 09:52
Last Modified:	09 Aug 2022 09:52
URI:	https://eprints.ums.edu.my/id/eprint/29148

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