Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future

Manzar Alam and Ghulam Md Ashraf and Kayenat Sheikh and Anish Khan and Sabeeha Ali and Md. Meraj Ansari and Mohd Adnan and Pasupuleti Visweswara Rao and Md. Imtaiyaz Hassan (2022) Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future. Frontiers in Pharmacology, 13 (.84587). pp. 1-14. ISSN 1666-9812

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URL: https://www.frontiersin.org/articles/10.3389/fphar...

Abstract

Caffeic acid (CA) has been present in many herbs, vegetables, and fruits. CA is a bioactive compound and exhibits various health advantages that are linked with its anti-oxidant functions and implicated in the therapy and prevention of disease progression of inflammatory diseases and cancer. The anti-tumor action of CA is attributed to its prooxidant and anti-oxidant properties. CA’s mechanism of action involves preventing reactive oxygen species formation, diminishing the angiogenesis of cancer cells, enhancing the tumor cells’ DNA oxidation, and repressing MMP-2 and MMP-9. CA and its derivatives have been reported to exhibit anti-carcinogenic properties against many cancer types. CA has indicated low intestinal absorption, low oral bioavailability in rats, and pitiable permeability across Caco-2 cells. In the present review, we have illustrated CA’s therapeutic potential, pharmacokinetics, and characteristics. The pharmacological effects of CA, the emphasis on in vitro and in vivo studies, and the existing challenges and prospects of CA for cancer treatment and prevention are discussed in this review.

Item Type:	Article
Keyword:	Caffeic acid , Cancer , Anti-cancer , Anti-oxidant activity , Bioavailability , Clinical trials
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	01 Aug 2022 08:34
Last Modified:	01 Aug 2022 08:34
URI:	https://eprints.ums.edu.my/id/eprint/29155

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