Effect of Kelulut honey supplementation on bone health in male rats on high-carbohydrate high-fat diet

Sophia Ogechi Ekeuku and Chin, Kok Yong and Nur Zuliani Ramli and Khairul Anwar Zarkasi and Fairus Ahmad (2021) Effect of Kelulut honey supplementation on bone health in male rats on high-carbohydrate high-fat diet. Tropical Journal of Pharmaceutical Research, 20 (6). pp. 1185-1192. ISSN 1596-9827 (E-ISSN) , 1596-5996 (P-ISSN)

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Abstract

Purpose: To determine the effects of Kelulut honey (KH) on the bone health of rats with metabolic syndrome. Methods: Male Wistar rats were randomized into normal control and metabolic syndrome s fed with a diet enriched with carbohydrate and fat. The rats in the metabolic syndrome arm were further assigned into the negative control group and honey group supplemented orally with Kelulut honey (1g/kg) daily for eight weeks. After the rats were sacrificed, the trabecular and cortical micro-architecture of the harvested femur was analysed using X-ray micro-computed tomography, while histomorphometric method was used to determine bone cell indices. Femoral biomechanical properties were analysed using a universal mechanical tester. Results: Total cross-sectional area, osteoid surface and volume, displacement and strain reduced significantly, while eroded surface increased significantly in the rats with metabolic syndrome than the normal rats (p < 0.05). The honey group showed a significant reduction in osteoclast surface than the normal healthy control (p < 0.05). Other skeletal parameters did not show a significant intergroup difference. Conclusion: Metabolic syndrome is harmful to bone health and honey has limited effects in reversing these negative effects.

Item Type:	Article
Keyword:	Calcium , Metabolic syndrome , Osteopenia , Osteoporosis , Bone health
Subjects:	Q Science > QL Zoology > QL1-991 Zoology > QL360-599.82 Invertebrates > QL461-599.82 Insects R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	04 Mar 2022 15:57
Last Modified:	04 Mar 2022 15:57
URI:	https://eprints.ums.edu.my/id/eprint/31835

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