Mallotus mollissimus and Solanum erianthum exhibit antikinase, antiphosphatase and anti-cancer properties

Nurul Ain Ismail and Azlinah Matawali and Lee, Ping Chin and How, Siew Eng and Latifah Saiful Yazan and Poh, Lucky Wah Goh and Jualang @ Azlan Abdullah Gansau (2021) Mallotus mollissimus and Solanum erianthum exhibit antikinase, antiphosphatase and anti-cancer properties. Journal of Pharmacy and Nutrition Sciences, 11. pp. 93-100. ISSN 1927-5951

	Text Mallotus Mollissimus and Solanum Erianthum Exhibit Antikinase, Antiphosphatase and Anti-Cancer Properties_ABSTRACT.pdf Download (62kB)
	Text Mallotus Mollissimus and Solanum Erianthum Exhibit Antikinase, Antiphosphatase and Anti-Cancer Properties.pdf Restricted to Registered users only Download (990kB) \| Request a copy

URL: https://setpublisher.com/wp-content/uploads/2021/1...

Abstract

Cancer is a leading cause of death worldwide and caused by dysregulated signal transduction from kinase and phosphatases. Inhibitors of kinase and phosphatase have demonstrated anticancer properties. Therefore, this study aimed to investigate the antikinase, antiphosphatase and cytotoxic properties of Mallotus mollissimus (M. mollissimus) and Solanum erianthum (S. erianthum). Toxic activities against PP1, MKK1 and MSG5 assays were demonstrated by S. erianthum methanol extract. Bioassay-guided fractionation of the methanolic extracts showed that chloroform fraction (CE) of M. mollissimus exhibited toxic activity against PP1. Meanwhile, CE of S. erianthum showed positive activity on PP1 assay. Column chromatography separation of the CE has revealed that fractions F1 and F2 of M. mollissimus are toxic against PP1. Meanwhile, F1 and F2 CE fractions of S. erianthum were positive against PP1 and F9 fraction showed toxic activity in PP1 assay. Chloroform extracts of both plants exhibit cytotoxicity activity against HeLa, CaOV3 and MCF7 cell lines. This study demonstrated the potential of M. mollissimus and S. erianthum extracts in antikinase, antiphosphatase and anti-cancer activities which warrant further purification and identification.

Item Type:	Article
Keyword:	Cytotoxicity , Kinase , Mallotus mollissimus , Phosphatase , Solanum erianthum
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	FACULTY > Faculty of Science and Natural Resources
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	30 Mar 2022 16:58
Last Modified:	30 Mar 2022 16:58
URI:	https://eprints.ums.edu.my/id/eprint/32159

Actions (login required)

View Item