Transcriptomic Response of Caenorhabditis Elegans Expressing Human Aß42Gene Treated with Salvianolic Acid A

Chee, Wah Yuen and Mardani Abdul Halim and Nazalan Najimudin and Ghows Azzam (2021) Transcriptomic Response of Caenorhabditis Elegans Expressing Human Aß42Gene Treated with Salvianolic Acid A. Current Science, 120. pp. 1882-1893. ISSN 0011-3891

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Abstract

Alzheimer’s disease is associated with the deposition of ß-amyloid peptide in the brain. A genome-wide transcriptomic study was performed to determine the response of transgenic Caenorhabditis elegans expressing full-length human Aß42 gene towards salvianolic acid A (Sal A). The genes associated with antioxidant response, gst-4, gst-10, spr-1 and trxr-2, were upregulated. Aß42 caused oxidative stress and the antioxidant response genes possibly provide some sort of protection to the nematode. trxr-2 gene product was also associated with the defence system and probably has a role in the lifespan of the nematode. Other genes involved in DNA replication, reproduction, immune response and antimicrobial activities were also found to be upregulated. Treatment of Sal A also increased the rate of reproduction in the nematode, and elevated its immunological protection system towards microorganisms. On the other hand, the genes responsible for ligand-gated cation channel, embryonic and postembryonic development, locomotion and neuromodulation of chemosensory neurons were found to be downregulated. As an effector, Sal A might conceivably reduce the movement of the nematode by interfering with neuronal transmission, and embryonic and postembryonic development.

Item Type: Article
Keyword: ß-amyloid peptide , Caenorhabditis elegans, Salvianolic acid A , Transcriptome
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry
Department: INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User: SAFRUDIN BIN DARUN -
Date Deposited: 08 Jun 2022 12:11
Last Modified: 08 Jun 2022 12:11
URI: https://eprints.ums.edu.my/id/eprint/32678

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