Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms

Jia, Wer Ee and Appalaraju Velaga and Rhanye Mac Guad and Vetriselvan Subramaniyan and Neeraj Kumar Fuloria and Shivkanya Fuloria and Ker, Woon Choy and Yuan, Seng Wu (2022) Deciphering Synsepalum dulcificum as an Arising Phytotherapy Agent: Background, Phytochemical and Pharmacological Properties with Associated Molecular Mechanisms. Sains Malaysiana, 51. pp. 199-208. ISSN 0126-6039

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Abstract

Medicinal plants with less side effects are paramount important for humankind to cure various ailments as compared to newly developed allopathic medicines. Synsepalum dulcificum Daniell (Sapotaceae), is well known as miracle fruits due to its distinctive taste-modifying property. This review aimed to discuss its recent reported pharmacological properties and associated molecular mechanisms as a novel phytotherapy agent. In addition, background, phytochemical analysis and toxicological studies were also discussed as the foundation and added values for this review. It was discovered that S. dulcificum is endowed with various classes of phytochemicals, such as flavonoids, tannins, alkaloids and saponins. This review ravelled that S. dulcificum is a potent medicinal plant associated with antioxidant, antidiabetic, antimicrobial, anticancer, anti-hyperuricemic, hepatoprotective, anti-hyperlipidaemic, and anticonvulsant activities, with less toxicity shown. Future research may explore further the corresponding phytochemicals, associated molecular mechanisms, toxicological and pharmacokinetic profile before subjecting to clinical testing.

Item Type:	Article
Keyword:	Miracle fruit , Molecular mechanism , Phytotherapy agent , Synsepalum dulcificum , Therapeutic activity
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology R Medicine > RV Botanic, Thomsonian, and eclectic medicine > RV1-431 Botanic, Thomsonian, and eclectic medicine
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	16 Jun 2022 15:01
Last Modified:	16 Jun 2022 15:01
URI:	https://eprints.ums.edu.my/id/eprint/32802

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