An Updated Review on the Role of Single Nucleotide Polymorphisms in COVID-19 Disease Severity: A Global Aspect

Jun, Wei Ng and Chong, Eric Tzyy Jiann and Lee, Ping Chin (2022) An Updated Review on the Role of Single Nucleotide Polymorphisms in COVID-19 Disease Severity: A Global Aspect. Current Pharmaceutical Biotechnology. ISSN 1389-2010 (P-ISSN) , 1873-4316 (E-ISSN)

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An Updated Review on the Role of Single Nucleotide Polymorphisms in COVID-19 Disease Severity _ABSTRACT.pdf
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URL: http://www.eurekaselect.com/article/120194

Abstract

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and recently has become a serious global pandemic. Age, gender, and comorbidities are known to be common risk factors for severe COVID-19 but are not enough to fully explain the magnitude of their effect on the risk of severity of the disease. Single nucleotide polymorphisms (SNPs) in several genes have been reported as a genetic factor contributing to COVID-19 severity. This comprehensive review focuses on the association between SNPs in four important genes and COVID-19 severity in a global aspect. We discuss a total of 39 SNPs in this review: five SNPs in the ABO gene, nine SNPs in the angiotensin-converting enzyme 2 (ACE2) gene, 19 SNPs in the transmembrane protease serine 2 (TMPRSS2) gene, and six SNPs in the toll-like receptor 7 (TLR7) gene. These SNPs data could assist in monitoring an individual’s risk of severe COVID-19 disease, and therefore personalized management and pharmaceutical treatment could be planned in COVID-19 patients.

Item Type:	Article
Keyword:	ABO , Covid-19 single nucleotide polymorphism , Angiotensin-converting enzyme 2 , Serine 2 , Toll-like receptor 7 , Transmembrane protease
Subjects:	Q Science > QR Microbiology > QR1-502 Microbiology
Department:	INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	13 Jul 2022 05:02
Last Modified:	13 Jul 2022 05:02
URI:	https://eprints.ums.edu.my/id/eprint/33200

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