Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Manzar Alam and Sarfraz Ahmed and Abdelbaset Mohamed Elasbal and Mohd Adnan and Shoaib Alam and Md. Imtaiyaz Hassan and Pasupuleti Visweswara Rao (2022) Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases. Frontiers in Oncology, 12. pp. 1-18. ISSN 2234 943X

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URL: https://www.frontiersin.org/articles/10.3389/fonc....

Abstract

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. The potential therapeutic effects of CA are mediated via repression and inhibition of transcription and growth factors. CA possesses potential anticancer and neuroprotective effects in human cell cultures and animal models. However, the biomolecular interactions and pathways of CA have been described highlighting the target binding proteins and signaling molecules. The current review focuses on CA’s chemical, physical, and pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. We further described CA’s characteristics and therapeutic potential and its future directions.

Item Type:	Article
Keyword:	Caffeic acid , Clinical trials , Diabetic neuropathy , Inflammatory diseases , Inhibitors , Targeted therapy
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC648-665 Diseases of the endocrine glands. Clinical endocrinology
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	17 Jul 2022 10:54
Last Modified:	17 Jul 2022 10:54
URI:	https://eprints.ums.edu.my/id/eprint/33349

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