TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

Suhaini Sudi and Tomohiro Tanaka and Sayaka Oda and Kazuhiro Nishiyama and Akiyuki Nishimura and Caroline Sunggip and Supachoke Mangmool and Takuro Numaga-Tomita and Motohiro Nishida (2019) TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy. Scientific reports, 9. pp. 1-13. ISSN 2045-2322

	Text TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy.ABSTRACT.pdf Download (70kB)
	Text TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy.pdf Restricted to Registered users only Download (3MB) \| Request a copy

URL: https://www.researchgate.net/publication/334258919...

Abstract

Myocardial atrophy, characterized by the decreases in size and contractility of cardiomyocytes, is caused by severe malnutrition and/or mechanical unloading. Extracellular adenosine 5′-triphosphate (ATP), known as a danger signal, is recognized to negatively regulate cell volume. However, it is obscure whether extracellular ATP contributes to cardiomyocyte atrophy. Here, we report that ATP induces atrophy of neonatal rat cardiomyocytes (NRCMs) without cell death through P2Y2 receptors. ATP led to overproduction of reactive oxygen species (ROS) through increased amount of NADPH oxidase (Nox) 2 proteins, due to increased physical interaction between Nox2 and canonical transient receptor potential 3 (TRPC3). This ATP-mediated formation of TRPC3-Nox2 complex was also pathophysiologically involved in nutritional deficiency-induced NRCM atrophy. Strikingly, knockdown of either TRPC3 or Nox2 suppressed nutritional deficiency-induced ATP release, as well as ROS production and NRCM atrophy. Taken together, we propose that TRPC3-Nox2 axis, activated by extracellular ATP, is the key component that mediates nutritional deficiency-induced cardiomyocyte atrophy.

Item Type:	Article
Keyword:	Myocardial atrophy , Cardiomyocytes , Heart
Subjects:	Q Science > QP Physiology > QP1-(981) Physiology > QP1-345 General Including influence of the environment R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC620-627 Nutritional diseases. Deficiency diseases
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	DG MASNIAH AHMAD -
Date Deposited:	21 Jul 2022 09:12
Last Modified:	21 Jul 2022 09:12
URI:	https://eprints.ums.edu.my/id/eprint/33416

Actions (login required)

View Item