Autophagy and EMT in cancer and metastasis: Who controls whom?

Rohit Gundamaraju and Wenying Lu and Manash K. Paul and Niraj Kumar Jha and Piyush Kumar Gupta and Shreesh Ojha and Indranil Chattopadhyay and Pasupuleti Visweswara Rao and Saeid Ghavami (2022) Autophagy and EMT in cancer and metastasis: Who controls whom? BBA - Molecular Basis of Disease, 1868. ISSN 0925-4439

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Abstract

Metastasis consists of hallmark events, including Epithelial-Mesenchymal Transition (EMT), angiogenesis, initiation of inflammatory tumor microenvironment, and malfunctions in apoptosis. Autophagy is known to play a pivotal role in the metastatic process. Autophagy has pulled researchers towards it in recent times because of its dual role in the maintenance of cancer cells. Evidence states that cells undergoing EMT need autophagy in order to survive during migration and dissemination. Additionally, it orchestrates EMT markers in certain cancers. On the other side of the coin, autophagy plays an oncosuppressive role in impeding early metastasis. This review aims to project the interrelationship between autophagy and EMT. Targeting EMT via autophagy as a useful strategy is discussed in this review. Furthermore, for the first time, we have covered the possible reciprocating roles of EMT and autophagy and its consequences in cancer metastasis.

Item Type:	Article
Keyword:	Autophagy , Epithelial-Mesenchymal Transition , EMT , Metastasis , Starvation , Tumor signalling pathways
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	DG MASNIAH AHMAD -
Date Deposited:	22 Jul 2022 15:25
Last Modified:	22 Jul 2022 15:25
URI:	https://eprints.ums.edu.my/id/eprint/33498

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