Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis

Larry Ellee Nyanti and Sing, Andy Ong Tang and Adam Malik Ismail and Lee, Ping Chew and Tze, Shin Leong (2022) Spontaneous tumour lysis syndrome as a rare presentation of thymoma with peripheral blood lymphocytosis. Proceedings of Singapore Healthcare, 31. pp. 1-3. ISSN 2010-1058 (P-ISSN) , 2059-2329 (E-ISSN)

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URL: https://journals.sagepub.com/doi/pdf/10.1177/20101...

Abstract

Tumour lysis syndrome is common in haematological malignancies but is rarely reported in solid tumours. Peripheral blood lymphocytosis is an autoimmune feature of thymomas. We report a 63-year-old female who presented with a mediastinal mass, spontaneous tumour lysis syndrome and a leukoerythroblastic picture on peripheral blood film. Bone marrow aspiration and trephine biopsy ruled out haematological malignancy. Subsequent biopsy of the mediastinal mass confirmed thymoma. This is the first reported case of thymoma with peripheral blood lymphocytosis presenting with spontaneous tumour lysis syndrome. Clinicians are reminded that solid tumours may masquerade as haematological malignancies in the presence of peripheral blood lymphocytosis, hence careful clinical evaluation is needed to differentiate between the two diagnoses.

Item Type:	Article
Keyword:	Eukoerythroblastic , Peripheral lymphocytosis , Thymoma , Tumour lysis syndrome
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	16 Aug 2022 09:33
Last Modified:	16 Aug 2022 09:33
URI:	https://eprints.ums.edu.my/id/eprint/33786

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