Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway

Ruth Naomi and Hasnah Bahari and Ong, Zhi Yi and Keong, Yong Yoke and Hashim Embong and Retnagowri Rajandram and Teoh, Soo Huat and Fezah Othman and Rosnani Hasham and Yin, Khoo Boon and Priyatharisni Kaniappan and Muhammad Dain Yazid and Zainul Amiruddin Zakaria (2022) Mechanisms of natural extracts of Andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway. International Journal of Molecular Sciences, 23 (5972). pp. 1-15. ISSN 1422-0067

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URL: https://www.mdpi.com/1422-0067/23/11/5972/htm

Abstract

Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of pharmacological activities, including anti-cancer properties, particularly in the lipid-dependent cancer pathway. Lipids act as crucial membrane-building elements, fuel for energy demanding activities, signaling molecules, and regulators of several cellular functions. Studies have shown that alterations in lipid composition assist cancer cells in changing microenvironments. Thus, compounds that target the lipid pathway might serve as potential anti-cancer therapeutic agents. The purpose of this review is to provide an overview of the medicinal chemistry and pharmacology of A. paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway.

Item Type:	Article
Keyword:	Natural extract , Cancer , Cellular signaling pathways , Target identification
Subjects:	Q Science > QK Botany > QK1-989 Botany R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SAFRUDIN BIN DARUN -
Date Deposited:	15 Sep 2022 15:36
Last Modified:	15 Sep 2022 15:36
URI:	https://eprints.ums.edu.my/id/eprint/34116

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