Tuberculosis Death Epidemiology and Its Associated Risk Factors in Sabah, Malaysia

Richard Avoi and Yau, Chun Liaw (2021) Tuberculosis Death Epidemiology and Its Associated Risk Factors in Sabah, Malaysia. International Journal of Environmental Research and Public Health, 18. pp. 1-13. ISSN 1660-4601

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Abstract

Tuberculosis (TB) is a leading killer from a single infectious agent globally. In 2019, Malaysia’s TB incidence rate was 92 per 100,000 population, and the TB mortality rate was estimated at 4 cases per 100,000 population per year. However, the state of Sabah had a higher burden of TB with a notification rate of 128 per 100,000 population and a TB case fatality rate of 8% compared to the national figure. This study aims to provide a comprehensive report on TB deaths epidemiology and its associated factors at a sub-national level. This nested case-control study used Sabah State Health Department TB surveillance data from the Malaysia national case-based TB registry (MyTB) between 2014 and 2018. Cases were defined as all-cause TB deaths that occurred before anti-TB treatment completion from the time of TB diagnosis. Controls were randomly selected from TB patients who completed anti-TB treatment. The TB mortality rate had increased significantly from 9.0/100,000 population in 2014 to 11.4/100,000 population in 2018. The majority of TB deaths occurred in the first two months of treatment. TB-related deaths were primarily due to advanced disease or disseminated TB, whereas non-TB-related deaths were primarily due to existing comorbidities. Many important independent risk factors for TB deaths were identified which are useful to address the increasing TB mortality rate.

Item Type:	Article
Keyword:	Tuberculosis , Case fatality , Mortality , Sabah , Malaysia
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC306-320.5 Tuberculosis
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	31 Oct 2022 12:21
Last Modified:	31 Oct 2022 12:21
URI:	https://eprints.ums.edu.my/id/eprint/34670

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