Jaafar Sadeq Makki (2014) Expression distribution of cancer stem cell, epithelial to mesenchymal transition and telomerase activity in breast cancer and their association with clinicopathological characteristic. Doctoral thesis, Universiti Malaysia Sabah.
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Abstract
Three novel concepts have been emerged in breast cancer biology: the role of cancer stem cells (CSC) in tumor initiation, and the involvement of an epithelial to mesenchymal transition (EMT) in the invasiveness and metastasis of cancer cells, along with the telomerase role in_ keeping the CSC immortal, and avoidino senescence. CSC are a small subpopulation of cells within tumors that initiate the tumor, telomerase is the intracellular enzyme responsible for the elongation of chromosomal telomer during each cell division, while EMT is the loss of epithelial differentiation and gained the mesenchymal phenotype.
| Item Type: | Thesis (Doctoral) |
|---|---|
| Keyword: | Breast cancer, Stem cells cancer, Cancer cells |
| Subjects: | R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens |
| Department: | FACULTY > Faculty of Medicine and Health Sciences |
| Depositing User: | DG MASNIAH AHMAD - |
| Date Deposited: | 13 Oct 2023 15:33 |
| Last Modified: | 13 Oct 2023 15:33 |
| URI: | https://eprints.ums.edu.my/id/eprint/37487 |
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