Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review

Allia Najmie Muhammad Yusuf and Mohd Fariz Amri and Azizah Ugusman and Adila A. Hamid and Norhazlina Abdul Wahab and Mohd Helmy Mokhtar (2023) Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review. International Journal of Molecular Sciences. pp. 1-18. ISSN 1422-0067

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Abstract

Endometrial receptivity is a state of the endometrium defined by its readiness for embryo implantation. When the receptivity of the endometrium is impaired due to hyperandrogenism or androgen excess, this condition can lead to pregnancy loss or infertility. Hyperandrogenism encompasses a wide range of clinical manifestations, including polycystic ovary syndrome (PCOS), idiopathic hirsutism, hirsutism and hyperandrogaenemia, non-classical congenital adrenal hyperplasia, hyperandrogenism, insulin resistance, acanthosis nigricans (HAIR-AN), ovarian or adrenal androgensecreting neoplasms, Cushing’s syndrome, and hyperprolactinaemia. Recurrent miscarriages have been shown to be closely related to elevated testosterone levels, which alter the endometrial milieu so that it is less favourable for embryo implantation. There are mechanisms for endometrial receptivity that are affected by excess androgen. The HOXA gene, aVβ3 integrin, CDK signalling pathway, MECA-79, and MAGEA-11 were the genes and proteins affect endometrial receptivity in the presence of a hyperandrogenic state. In this review, we would like to explore the other manifestations of androgen excess focusing on causes other than PCOS and learn possible mechanisms of endometrial receptivity behind androgen excess leading to pregnancy loss or infertility

Item Type:	Article
Keyword:	hyperandrogenism; endometrial receptivity; androgen excess; infertility
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens R Medicine > RG Gynecology and obstetrics > RG1-991 Gynecology and obstetrics > RG159-208 Functional and systemic disorders. Endocrine gynecology
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	13 Oct 2023 15:53
Last Modified:	13 Oct 2023 15:53
URI:	https://eprints.ums.edu.my/id/eprint/37494

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