A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers

Jalviana Lansayan and Nur Salwani Bakar and Ismail Che Noh and Abdah Karimah Che Md Nor and Imran Ahmad and Abu Bakar Ruzilawati (2023) A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers. Vietnamese Journal for Medical Biotechnology and Medicine Incorporating Advances in Regenerative Medicine, 10 (2). pp. 1-8.

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URL: http://bmrat.org/index.php/BMRAT/article/view/794

Abstract

Introduction: Hepatitis C virus (HCV) infection frequently leads to liver complications, such as fibrosis, cirrhosis, and hepatocellular carcinoma. The incidence of HCV infection transmission among drug abusers is concerning. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine secreted during innate and adaptive immune responses and plays a pivotal role in chronic inflammatory diseases. Functional single nucleotide polymorphisms in IL-1β cause it to play different roles in disease susceptibility and progression. This study aimed to investigate the association between genetic polymorphisms of pro-inflammatory cytokines (IL-1β) and HCV infection susceptibility in Malay male drug abusers. Methods: In total, 48 male Malay drug abusers were included in this retrospective case-control study. Genomic DNA was extracted from whole blood samples and analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the IL1β rs16944 and rs1143634 polymorphisms. Results: Analysis of IL-1β rs1143634 revealed that the C/C genotype was common in both the case and control groups; however, no statistical significance was observed (p = 0.068, χ 2= 3.755). Genotyping of IL-1β demonstrated that all samples were of the homozygous mutant type (T/T). Conclusion: There was no association between IL-1β polymorphism (rs1143634 and rs16944) and hepatitis C infection susceptibility among Malay male drug abusers.

Item Type:	Article
Keyword:	hepatitis C, interleukin-1β (IL-1β), polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), Malay male, single nucleotide polymorphism (SNP)
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC799-869 Diseases of the digestive system. Gastroenterology
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	12 Jan 2024 09:19
Last Modified:	12 Jan 2024 09:19
URI:	https://eprints.ums.edu.my/id/eprint/37908

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