Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats

Nur Hanisah Azmi and Norsharina Ismail and Mustapha Umar Imam and Der Jiun Ooi and Zhang Yida and Ahmad Hazim Abdul Aziz and Mohamad Norisham Mohamad Rosdi (2023) Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats. Journal of Functional Foods, 105. pp. 1-12. ISSN 1756-4646

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Abstract

A strong association presents between excessive amyloid-β (Aβ) buildup and oxidative stress with Alzheimer’s disease (AD). In view of the multifaceted neuroprotective effects of some dietary elements, the beneficial effect of germinated brown rice was investigated using a high fat/cholesterol diet (HFCD)-induced sporadic rat model of AD. Seven groups, including normal control, HFCD, and HFCD treated with Donepezil, Simvastatin, Probucol, and germinated brown rice ethyl acetate extract (GBR-EA; 100 and 200 mg/kg bw) were included in the present study. Biochemical assays, brain lipid peroxidation, mRNA and protein levels involved in Aβ processing and metabolism pathways were analyzed. HFCD-fed rats exhibited increased brain lipid peroxidation and Aβ levels, as well as altered expressions of proteins involved in Aβ generation, degradation and clearance. GBR-EA treatment groups showed significant reduction in lipid peroxidation and Aβ levels when compared to HFCD group. The effects of GBR-EA on Aβ levels are likely through the modulation of BACE1 and Presenilins, as well as induction of Aβ clearance and degradation. The findings revealed the potential use of germinated brown rice to attenuate HFCD diet-induced neurodegenerative alterations, likely due to reduced brain inflammation, as well as modulation of Aβ processing and metabolism pathways.

Item Type:	Article
Keyword:	Germinated brown rice, High fat/cholesterol diet, Oxidative stress, Amyloid-β, Alzheimer’s disease
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry > RC346-429 Neurology. Diseases of the nervous system Including speech disorders > RC435-571 Psychiatry > RC512-569.5 Psychopathology > RC512-528 Psychoses R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology > RM214-258 Diet therapy. Dietary cookbooks
Department:	FACULTY > Faculty of Food Science and Nutrition
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	29 Feb 2024 10:30
Last Modified:	29 Feb 2024 10:30
URI:	https://eprints.ums.edu.my/id/eprint/38408

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