Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats

Ahmad Safiyyu’d-din Bin Hisamuddin and Ruth Naomi and Khairul Aiman Manan and Hasnah Bahari and Muhammad Dain Yazid and Fezah Othman and Hashim Embong and Siti Hadizah Jumidil and Mohd Khairi Hussain and Zainul Amiruddin Zakaria (2023) Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats. Frontiers in Pharmacology, 14. pp. 1-12. ISSN 1666-9812

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URL: https://www.frontiersin.org/journals/pharmacology/...

Abstract

This study assessed the toxicity of lutein-rich purple sweet potato leaf (PSPL) extract in male Sprague–Dawley rats. Methods and study design: A total of 54 adult male Sprague–Dawley rats were used. For the acute toxicity study, three rats in the acute control group were fed 2,000 mg/kg of PSPL for 14 days. The subacute toxicity study included six rats each in four groups administered 50, 250, 500, or 1,000 mg/kg for 28 days and observed for further 14 days without treatment in the subacute control and subacute satellite groups. Changes in body weight; blood biochemistry; hematological parameters; relative organ weight; and histological sections of the heart, kidney, liver, pancreas, aorta, and retina were observed for signs of toxicity. Results: The gradual increase in weekly body weight, normal level full blood count, normal liver and kidney profile, relative organ weight, and histological sections of all stained organ tissue in the treated group compared with the acute, subacute, and satellite control groups demonstrated the absence of signs of toxicity. Conclusion: Lutein-rich PSPL extract shows no signs of toxicity up to 2,000 mg/kg/day.

Item Type:	Article
Keyword:	Medicinal plant, Purple sweet potato, Plant extract, Phytochemicals, Bioactive compounds, Toxicity, Animal study
Subjects:	Q Science > QK Botany > QK1-989 Botany R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	02 May 2024 16:46
Last Modified:	02 May 2024 16:46
URI:	https://eprints.ums.edu.my/id/eprint/38602

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