Factors Associated With Loss to Follow Up During Treatment of Latent Tuberculosis Infection in Children Under 5 Years of Age in Sabah, Malaysia

Sheila Miriam Mujin and Richard Avoi and Roddy Teo (2023) Factors Associated With Loss to Follow Up During Treatment of Latent Tuberculosis Infection in Children Under 5 Years of Age in Sabah, Malaysia. Malaysian Journal of Medicine and Health Sciences, 19. pp. 1-6. ISSN 2636-9346

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URL: https://medic.upm.edu.my/our_journal/volume_19_202...

Abstract

Loss to follow up remains one of the main problems in the treatment of latent tuberculosis infection (LTBI) in the state of Sabah, Malaysia. This study aims to identify the risk factors for loss to follow-up among LTBI treated TB contacts in children under 5 years of age, who did not complete 180 dosages of treatment within 6 to 9 months. Methods: This retrospective cohort study used anonymised data taken from the Malaysia national case-based TB registry (MyTB) between 2017 and 2019. To identify factors related with loss to follow-up, a logistic regression analysis was performed. Results: Of the 1334 treated LTBI cases, 10.4% were loss-to-follow-up. The mean age of study participants was 2.3 years, with 50.2% males. Factors associated with loss to follow-up include index-contact relationship i.e., Extended family (aOR = 1.82, 95% CI = 1.19, 2.77) and PTB index in whom the treatment outcome is loss to follow up (aOR = 4.84, 95% CI = 1.96, 11.95). Rural living was associated with less loss to follow (adjusted odds ratio (aOR) = 0.40, 95% confidence interval (CI) = 0.26, 0.61). Conclusion: Despite commendable efforts, the problem of loss to follow during LTBI treatment in children persisted. In spite of the inherent limitations of the study, the associated factors identified in this study can be used as a basis for future initiatives to strengthen LTBI management.

Item Type:	Article
Keyword:	Latent Tuberculosis Infection; Preventive therapy; Loss to follow up
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC799-869 Diseases of the digestive system. Gastroenterology
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	04 Jul 2024 14:04
Last Modified:	04 Jul 2024 14:04
URI:	https://eprints.ums.edu.my/id/eprint/39017

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