Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia

Wen-Li Tee and Fredie Robinson and Richard Avoi and Prabakaran Dhanaraj and Nirmal Kaur and Nur Hasanah Sanudin (2023) Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia. Malaysian Journal of Medicine and Health Sciences, 19. pp. 1-16. ISSN 2636-9346

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Abstract

Introduction: The association between colorectal cancer (CRC), ethnicity, and dietary practices have been well studied. However, limited studies have been conducted to assess dietary practices and ethnicity in Sabah on risk of CRC. This study aimed to assess the risk and protective factors in dietary practices and the inclusion of ethnicity and dietary practices as risk predictors for CRC. Methods: 148 CRC patients, 609 controls were recruited in this case-control study. Logistic regression analyses were performed to determine significant predictors of CRC. Prediction model was computed using Logistic Regression (LR) and C5 Decision Tree algorithms and compared. Results: Age 60-69 (aOR = 7.44, 95% CI = 3.69-15.00); male (aOR = 4.49, 95% CI = 2.67-7.54), Chinese (aOR = 32.32, 95% CI = 7.20-145.13); moderate physical activity (aOR = 3.67, 95% CI = 2.03-6.63), pickled mango (aOR = 5.66, 95% CI = 1.62-19.81), pork (aOR = 2.29, 95% CI = 1.09-4.79) increased the odds of developing CRC. No comorbidities (aOR = 0.53, 95% CI = 0.31-0.91), tertiary education attainment (aOR = 0.18, 95% CI = 0.07-0.43) were protective against CRC. Hosmer-Lemeshow test indicated good fit of the model (p =.946) and excellent discriminatory power (AUC=0.877). LR prediction model demonstrated better overall accuracy (89.2%), discriminatory power (AUC=0.82), sensitivity (77%), and specificity (91%) than the C5 Model. Conclusion: Frequent consumption of pickled mangoes and pork increased CRC risk among the Sabah population. Inclusion of ethnicity and dietary practices as predictors could potentially improve risk stratification of the Sabah population for early CRC screening

Item Type:	Article
Keyword:	Colorectal cancer; Ethnicity; Dietary practices; Prediction; Screening
Subjects:	R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine > RA773-788 Personal health and hygiene Including clothing, bathing, exercise, travel, nutrition, sleep, sex hygiene R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	11 Jul 2024 16:24
Last Modified:	11 Jul 2024 16:24
URI:	https://eprints.ums.edu.my/id/eprint/39058

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