Metabolite Alteration Associated with Dabai Pulp Oil Supplementation in Hypercholesterolemic Rats

Noor Atiqah Aizan Abdul Kadir and Azrina Azlan and Maisarah Abdul Mutalib (2024) Metabolite Alteration Associated with Dabai Pulp Oil Supplementation in Hypercholesterolemic Rats. Malaysian Journal of Medicine and Health Sciences, 20 (3). pp. 1-8. ISSN 2636-9346

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URL: https://medic.upm.edu.my/jurnal_kami/volume_20_202...

Abstract

Introduction: Metabolomic analyses have become paramount in unveiling the therapeutic capacities of bioactive agents. Dabai pulp oil (DPO) has emerged as a prospective agent against hypercholesterolemia. This investigation delineates the metabolic imprints of DPO’s therapeutic actions using ¹H NMR-based urinary metabolomic profiling. Methods: Male Sprague-Dawley rats were first exposed to a high-cholesterol regimen to simulate hypercholesterolemia. Following this induction, they were transitioned to a DPO-infused diet. The ensuing metabolic variations were tracked using ¹H NMR-based urinary metabolomic analysis. Results: The metabolic landscape displayed discernible shifts post-DPO administration, underlining its therapeutic potential. There was a marked decrement in the concentrations of pivotal metabolites such as creatinine, succinate, pyruvate, acetate, TMAO, and choline (p<0.05). Notably, an augmented taurine concentration after DPO administration spotlighted the oil’s antioxidative and anti-inflammatory prowess (p<0.05). These observations underscore DPO’s proficiency in rectifying metabolic aberrations inherent to hypercholesterolemia, particularly affecting energy transduction and cardiovascular function. Conclusion: This empirical evidence bolsters the notion that DPO harbours potent therapeutic virtues for hypercholesterolemia amelioration. Nevertheless, in-depth explorations are quintessential to decoding its holistic therapeutic pathways, fortifying its role in future targeted interventions.

Item Type:	Article
Keyword:	Dabai pulp oil, Hypercholesterolemia, Functional food, Metabolomics
Subjects:	Q Science > QP Physiology > QP1-(981) Physiology > QP1-345 General Including influence of the environment R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC666-701 Diseases of the circulatory (Cardiovascular) system
Department:	FACULTY > Faculty of Food Science and Nutrition
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	05 Aug 2024 11:20
Last Modified:	05 Aug 2024 11:20
URI:	https://eprints.ums.edu.my/id/eprint/39467

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