Menopausal hormone therapy and risk of venous thromboembolism: the story so far

Mohsen M.A. Abdelhafez and Karim A. M. Ahmed and Nashwa A.M. Ahmed and Mohd H. Ismail and Mohd Nazri Mohd Daud and Aya M. Eldiastey and Mohd Fariz Amri and Mohammad Saffree Jeffree and Fairrul Masnah @ Kadir and Dg Marshitah Pg Baharuddin and Mohammad Firdaus Bolong @ Mohd Darwis and Mohd Firdaus Hayati and Nornazirah Azizan and Doreen Sumpat and Syed Sharizman Syed Abdul Rahim and Win W. Than and Mohd Y. Ibrahim and Zhen Z. Lo and May, Zaw Soe (2024) Menopausal hormone therapy and risk of venous thromboembolism: the story so far. African Journal of Reproductive Health, 28. pp. 122-129. ISSN 2141-3606

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Abstract

Menopausal hormone therapy (MHT) is known to increase the risk of venous thromboembolism (VTE), which includes deep vein thrombosis, pulmonary embolism, and less frequently cerebral vein thrombosis, but the absolute risk for a given patient is very low. After starting MHT, the risk of VTE seems to be at its highest, declining to the non-HRT user baseline level of risk after stopping. Whether estrogen-only or estrogen-progestin HRT combination is linked to a similar risk of VTE is unclear from the available evidence. The aim of this study is to evaluate the risks of developing VTE in relation to different types as well as different modes of administration of MHT through a database search including PubMed, MEDLINE, Google Scholar, Cochrane Library, and others in order to provide the women carers with the up-to-date and evidence-based guidelines and recommendations while counseling the post-menopausal women enquiring on use of hormonal therapies either to alleviate the menopausal symptoms or to prevent the longterm sequelae of estrogen deficiency.

Item Type:	Article
Keyword:	Menopausal hormone therapy, Post-menopausal women, Estrogen, Combined estrogen and progestogen, Venous thromboembolism
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RG Gynecology and obstetrics > RG1-991 Gynecology and obstetrics > RG159-208 Functional and systemic disorders. Endocrine gynecology
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	20 Sep 2024 09:49
Last Modified:	20 Sep 2024 09:49
URI:	https://eprints.ums.edu.my/id/eprint/41068

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