The role of estrogen across multiple disease mechanisms

Xiuting Xiang and Praneetha Palasuberniam and Rahmawati Pare (2024) The role of estrogen across multiple disease mechanisms. Current Issues in Molecular Biology, 46 (8). pp. 1-27.

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Abstract

Estrogen is a significant hormone that is involved in a multitude of physiological and pathological processes. In addition to its pivotal role in the reproductive system, estrogen is also implicated in the pathogenesis of a multitude of diseases. Nevertheless, previous research on the role of estrogen in a multitude of diseases, including Alzheimer’s disease, depression, cardiovascular disease, diabetes, osteoporosis, gastrointestinal diseases, and estrogen-dependent cancers, has concentrated on a single disease area, resulting in a lack of comprehensive understanding of cross-disease mechanisms. This has brought some challenges to the current treatment methods for these diseases, because estrogen as a potential therapeutic tool has not yet fully developed its potential. Therefore, this review aims to comprehensively explore the mechanism of estrogen in these seven types of diseases. The objective of this study is to describe the relationship between each disease and estrogen, including the ways in which estrogen participates in regulating disease mechanisms, and to outline the efficacy of estrogen in treating these diseases in clinical practice. By studying the role of estrogen in a variety of disease mechanisms, it is hoped that a more accurate theoretical basis and clinical guidance for future treatment strategies will be provided, thus promoting the effective management and treatment of these diseases.

Item Type:	Article
Keyword:	estrogen; mechanism; multiple disease; Alzheimer’s disease; depression; cardiovascular disease; diabetes; osteoporosis; gastrointestinal diseases; estrogen-dependent cancers
Subjects:	Q Science > QP Physiology > QP1-(981) Physiology > QP501-801 Animal biochemistry R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry > RC346-429 Neurology. Diseases of the nervous system Including speech disorders > RC435-571 Psychiatry > RC512-569.5 Psychopathology > RC512-528 Psychoses
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	14 Oct 2024 09:59
Last Modified:	14 Oct 2024 09:59
URI:	https://eprints.ums.edu.my/id/eprint/41242

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