Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light

Mazdida Sulaiman and Layane behairy and Veeranoot Nissapatorn and Mohammed Rahmatullah and Jhonnel Villegas and Helina Jean Dupa and Ricksterlie C. Verzosa and Karma G. Dolma and Muamad Shabaz and Scholastica Lanting and Nor Azizun Rusdi and Nor Hayati Abdullah and Mohammed Khaled Break and Teng, Jin Khoo and Wei Wang and Christophe Patrice Andie Wiart (2024) Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light. Pharmaceutical Biology, 62 (1). pp. 713-766. ISSN 1388-0209

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URL: https://www.tandfonline.com/doi/full/10.1080/13880...

Abstract

Context: he emergence of pan-resistant bacteria requires the development of new antibiotics and antibiotic potentiators. Objective: his review identifies antibacterial phenolic compounds that have been identified in Asian and Pacific Angiosperms from 1945 to 2023 and analyzes their strengths and spectra of activity, distributions, molecular masses, solubilities, modes of action, structures-activities, as well as their synergistic effects with antibiotics, toxicities, and clinical potential. Methods: All data in this review was compiled from Google Scholar, PubMed, Science Direct, eb of Science, and library search; other sources were excluded. e used the following combination of keywords: ‘Phenolic compound’, ‘Plants’, and ‘Antibacterial’. his produced 736 results. ach result was examined and articles that did not contain information relevant to the topic or coming from non-peer-reviewed journals were excluded. ach of the remaining 467 selected articles was read critically for the information that it contained. Results: Out of ~350 antibacterial phenolic compounds identified, 44 were very strongly active, mainly targeting the cytoplasmic membrane of Gram-positive bacteria, and with a molecular mass between 200 and 400g/mol. 2-Methoxy-7-methyljuglone, [6]-gingerol, anacardic acid, baicalin, vitexin, and malabaricone A and B have the potential to be developed as antibacterial leads. Conclusions: Angiosperms from Asia and the Pacific provide a rich source of natural products with the potential to be developed as leads for treating bacterial infections.

Item Type:	Article
Keyword:	Angiosperms, Antibiotics, Asia-Pacific, Inflammation, Superbugs
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology > RM265-267 Antibiotic therapy. Antibiotics S Agriculture > SB Plant culture > SB1-1110 Plant culture > SB403-450.87 Flowers and flower culture. Ornamental plants
Department:	INSTITUTE > Institute for Tropical Biology and Conservation
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	20 Nov 2024 12:32
Last Modified:	20 Nov 2024 12:32
URI:	https://eprints.ums.edu.my/id/eprint/41980

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