Antibiotic use in a co-infection of respiratory syncytial virus and pathogenic bacteria in children in a resource-limited setting in northeast Peninsular Malaysia

Liew, Constance Sat Lin and Rhanye Mac Guad and Taylor-Robinson, A.W and Kew, Seih Teck and Mandrinos, S and Elsonmond Vick Duin and Mexmollen Marcus and Chua, Shee Wen and Ho, Hui Lian and Lo, Zhen Zhen and Gan, S.H. and Wu, Y.S. and Doreen Sumpat and Mohamad Azlan Awang and Md. Shamsur Rahman and Azzani, M. (2024) Antibiotic use in a co-infection of respiratory syncytial virus and pathogenic bacteria in children in a resource-limited setting in northeast Peninsular Malaysia. Tropical Biomedicine, 41. pp. 310-315. ISSN 0127-5720

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URL: https://msptm.org/vol-41-3/

Abstract

To investigate co-infection of bacterial isolates associated with respiratory syncytial virus (RSV) in children aged less than two years who were admitted to hospital with confirmed lower respiratory tract infection (LRTI) in Kelantan, Malaysia. The demographic data, clinical history, case management, haematological as well as infectious parameters (white blood cell differential and count, plus C-reactive protein, CRP) of the patients were systematically recorded. Less than one-third of cases were RSV-positive (21.03% and 26.23% were diagnosed as acute bronchiolitis or pneumonia, respectively). Blood cultures from approximately 10% of patients demonstrated growth of Haemophilus influenzae, Staphylococcus aureus, coagulase-negative Staphylococcus, Pseudomonas stutzeri, haemolytic Streptococcus group A, and Bacillus subtilis. Further analysis indicated that children with positive bacterial growth had an insignificant predictive value of CRP (2.32–7.16 mg/dl). The total white cell counts were 2.97-7.33 x 109/L despite increased lymphocyte values in the bacteria-positive blood culture. Platelet counts were also within normal limits except for a single case of H. influenzae infection (685.50 x 109/L). Interestingly, 95.01% of patients were treated with antibiotics; 66.23% of RSV infection cases were administered with a combination of antibiotics and 33.77% with only a single antibiotic. The data indicate that the use of antibiotics, either singly or in combination, is not always effective in treating LRTI in infants. Alternative therapeutic regimens should be considered, especially in Asian countries that may have limited resources.

Item Type:	Article
Keyword:	Antibiotic, Co-infection, Lower respiratory tract infection, LRTI, respiratory syncytial virus (RSV); Kelantan Malaysia.
Subjects:	R Medicine > RJ Pediatrics > RJ1-570 Pediatrics > RJ370-550 Diseases of children and adolescents R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology > RM265-267 Antibiotic therapy. Antibiotics
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	16 Dec 2024 10:49
Last Modified:	16 Dec 2024 10:49
URI:	https://eprints.ums.edu.my/id/eprint/42161

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