Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series

Huan, Nai-Chien and Ng, Khai Lip and Larry Ellee Nyanti and Khaw, Jing Yi and Lee, Jiun Hang and Nur Husna Mohd Aminudin and Dahziela Yunus and Nusaibah Azman and Maryam Ahmad Sharifuddin and Hema Yamini Ramarmuty and Kunji Kannan Sivaraman Kannan (2024) Utilizing medical thoracoscopy for the diagnosis of B-cell lymphoma presenting with pleural effusion: A case series. Respirology Case Reports, 12. pp. 1-6. ISSN 2051-3380

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URL: https://onlinelibrary.wiley.com/doi/10.1002/rcr2.7...

Abstract

A third of patients with non-Hodgkin’s lymphoma (NHL) develop pleural effusion during the disease course for various reasons. In most cases, lymphoma-related pleural effusion is a manifestation of widespread systemic disease, signifying a high tumour burden and therefore, a poorer prognosis. On the other hand, primary pleural lymphomas (PPLs) exhibit exclusive or dominant involvement of serous cavities, without detectable solid tumour masses. PPL is an uncommon disease and is of two types: primary effusion lymphoma (PEL) and diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI). PPLs not related to PELs and DLBCL-CIs are exceedingly rare. Herein, we describe four patients with biopsy proven B-cell NHL. One had no extra-pleural involvement at the time of diagnosis, indicating PPL. In all cases, histopathological examination of pleural biopsies obtained via medical thoracoscopy (MT) were crucial in clinching the final diagnosis. Clinicians are alerted to the potential relationship between exudative effusion and NHL as well as the role of MT in the diagnosis of B-cell NHL.

Item Type:	Article
Keyword:	Lymphoma, Malignant effusion, Medical thoracoscopy, Pleural effusion
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	16 Dec 2024 10:59
Last Modified:	16 Dec 2024 10:59
URI:	https://eprints.ums.edu.my/id/eprint/42163

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