Mazdida Sulaiman and Khoshnur Jannat and Veeranoot Nissapatorn and Mohammed Rahmatullah and Alok K. Paul and Maria de Lourdes Perei and Mogana Rajagopal and Monica Suleiman and Mark S. Butler and Mohammed Khaled Bin Break and Jean-Frédéric Weber and Polrat Wilairatana and Christophe Wiart (2022) Antibacterial and antifungal alkaloids from Asian angiosperms: distribution, mechanisms of action, structure-activity, and clinical potentials. Antibiotics, 11. pp. 1-38.
![[img]](https://eprints.ums.edu.my/style/images/fileicons/text.png) |
Text
FULL TEXT.pdf Restricted to Registered users only Download (1MB) | Request a copy |
Abstract
The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1979 to 2022. One hundred and forty-one antibacterial and/or antifungal alkaloids were identified during this period, mainly from basal angiosperms. The most active alkaloids are mainly planar, amphiphilic, with a molecular mass between 200 and 400 g/mol, and a polar surface area of about 50 Å2, and target DNA and/or topoisomerase as well as the cytoplasmic membrane. 8-Acetylnorchelerythrine, cryptolepine, 8-hydroxydihydrochelerythrine, 6-methoxydihydrosanguinarine, 2′-nortiliacorinine, pendulamine A and B, rhetsisine, sampangine, tiliacorine, tryptanthrin, tylophorinine, vallesamine, and viroallosecurinine yielded MIC ≤ 1 µg/mL and are candidates for the development of lead molecules.
| Item Type: | Article |
|---|---|
| Keyword: | Medicinal plants, Antibacterial, Antifungal, Alkaloids, Asia |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology > RM265-267 Antibiotic therapy. Antibiotics R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) |
| Department: | INSTITUTE > Institute for Tropical Biology and Conservation |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 23 Dec 2024 11:14 |
| Last Modified: | 23 Dec 2024 11:14 |
| URI: | https://eprints.ums.edu.my/id/eprint/42366 |
Actions (login required)
 |
View Item |