A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases

Nur Zuliani Ramli and Mohamad Fairuz Yahaya and Ikuo Tooyama and Hanafi Ahmad Damanhuri (2020) A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases. Antioxidants, 9. pp. 1-41.

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Abstract

Nutraceuticals have been extensively studied worldwide due to its neuroprotective effects in in vivo and in vitro studies, attributed by the antioxidative properties. Alzheimer (AD) and Parkinson disease (PD) are the two main neurodegenerative disorders that are discussed in this review. Both AD and PD share the similar involvement of oxidative stress in their pathophysiology. Nutraceuticals exert their antioxidative effects via direct scavenging of free radicals, prevent damage to biomolecules, indirectly stimulate the endogenous antioxidative enzymes and gene expressions, inhibit activation of pro-oxidant enzymes, and chelate metals. In addition, nutraceuticals can act as modulators of pro-survival, pro-apoptotic, and inflammatory signaling pathways. They have been shown to be effective particularly in preclinical stages, due to their multiple mechanisms of action in attenuating oxidative stress underlying AD and PD. Natural antioxidants from food sources and natural products such as resveratrol, curcumin, green tea polyphenols, and vitamin E are promising therapeutic agents in oxidative stress-mediated neurodegenerative disease as they have fewer adverse effects, more tolerable, cheaper, and sustainable for long term consumption.

Item Type:	Article
Keyword:	Oxidative stress, Free radical scavenger, Lipid peroxidation, Metal chelator, Antioxidant enzymes, Inflammation, Cell survival, Apoptosis
Subjects:	Q Science > QP Physiology > QP1-(981) Physiology > QP1-345 General Including influence of the environment R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA421-790.95 Public health. Hygiene. Preventive medicine
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	31 Dec 2024 09:20
Last Modified:	31 Dec 2024 09:20
URI:	https://eprints.ums.edu.my/id/eprint/42463

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