Mimi Azreen Abdullah and Saleh Mohammed Abdullah Saleh Mohammed and Subbiah Vijay Kumar and Mohammad Zahirul Hoque (2019) Concurrent juvenile myelomonocytic leukemia with thalassemia in a case with plasmodium knowlesi infection from Sabah, Malaysian Borneo. Hematology Reports 2019, 11. pp. 46-48.
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Abstract
A 3-year-old male child was presented with worsening abdominal pain, abdominal distension, lethargy, pallor and hepatosplenomegaly. The patient had multiple outpatient visits in the past and was treated with oral antibiotics, oral anthelmintic agents, albeit with minimal benefit. The patient also had non-neutropenic pyrexia spikes and oral ulcers. The patient was an adopted child; hence details about his biological parents’ previous history were unclear. Differential diagnosis of Chronic Myelomonocytic Leukemia (CMML), Juvenile Myelomonocytic Leukemia (JMML), Gaucher’s disease, Thalassemia and discrete pancreatic pathology was considered. Hemoglobin electrophoresis was indicative of thalassemia. Also, molecular detection method by polymerase chain reaction confirms a concurrent infection with Plasmodium knowlesi malaria. The BCR-ABL fusion gene was found to be negative. Correlating with peripheral monocytosis, bone marrow aspiration and trephine biopsy with blasts only 3-4% and hepatosplenomegaly, a diagnosis of JMML was established. We present a rare phenomenon with an overlap of signs and symptoms between JMML, underlying thalassemia, and Plasmodium knowlesi, posing a diagnostic challenge to physicians.
| Item Type: | Article |
|---|---|
| Keyword: | Chronic Myelomonocytic Leukemia, Juvenile Myelomonocytic Leukemia, Thalassemia |
| Subjects: | R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC633-647.5 Diseases of the blood and blood-forming organs R Medicine > RJ Pediatrics > RJ1-570 Pediatrics > RJ370-550 Diseases of children and adolescents |
| Department: | FACULTY > Faculty of Medicine and Health Sciences |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 31 Dec 2024 11:18 |
| Last Modified: | 31 Dec 2024 11:18 |
| URI: | https://eprints.ums.edu.my/id/eprint/42490 |
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