Jiayu He and Yuandong Liu and Xiaofeng Zeng and Yan Tong and Run Liu and Kan Wang and Xiangdong Shangguan and Guanzhou Qiu and Coswald Stephen Sipaut @ Mohd Nasri (2023) Silicon nitride bio ceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties. Journal of Functional Biomaterials, 14. pp. 1-16.
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Abstract
Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from common production methods. SEM and pore distribution analysis revealed the microstructure of microwave-sintered silicon nitride with obvious pores. Mechanical performance analysis shows that microwave sintering can improve the mechanical properties of silicon nitride. The CCK-8 method was used to demonstrate that microwave-sintered silicon nitride has no cytotoxicity and good cytocompatibility. From SEM and CLSM observations, it was observed that there was good adhesion and cross-linking of cells during microwave-sintered silicon nitride, and the morphology of the cytoskeleton was good. Microwave-sintered silicon nitride has been proven to be non-cytotoxic. In addition, the antibacterial ability of microwave sintered silicon nitride against Staphylococcus aureus and Escherichia coli was tested, proving that it has a good antibacterial ability similar to the silicon nitride prepared by commonly used processes. Compared with silicon nitride prepared by gas pressure sintering technology, microwave-sintered silicon nitride has excellent performance in mechanical properties, cell compatibility, and antibacterial properties. This indicates its enormous potential as a substitute material for manufacturing bone implants.
| Item Type: | Article |
|---|---|
| Keyword: | Silicon nitride, Microwave sintering, Mechanical properties, Cytocompatibility, Anti-bacteria |
| Subjects: | R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine T Technology > TA Engineering (General). Civil engineering (General) > TA1-2040 Engineering (General). Civil engineering (General) |
| Department: | FACULTY > Faculty of Engineering |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 13 Jan 2025 16:18 |
| Last Modified: | 13 Jan 2025 16:18 |
| URI: | https://eprints.ums.edu.my/id/eprint/42565 |
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