Emergence of non-classical genotype constellations of G9P[8] rotavirus strains in diarrheic children in Sabah, Malaysia

Siat Yee Fong and Yuki Akari and Lia Natasha Amit and Jecelyn Leaslie John and Abraham Zefong Chin and Satoshi Komoto and Kamruddin Ahmed (2024) Emergence of non-classical genotype constellations of G9P[8] rotavirus strains in diarrheic children in Sabah, Malaysia. Infection, Genetics and Evolution, 125. pp. 1-15. ISSN 1567-1348

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Abstract

G9P[8] has been the predominant rotavirus A (RVA) genotype in Malaysia since the 2000s. However, the overall genetic makeup and evolution of Malaysian G9P[8] strains are still unknown. Therefore, this study aimed to evaluate and characterize the complete genomes of three G9P[8] RVA strains isolated from diarrheic children under five years old in Sabah. Contrary to the classical Wa-like constellation, these strains contained a DS-1-like genotype. Two strains, namely L202 and L234, were genotype G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1, while one (KN102) was genotype G9-P[8]-I1-R1-C1-M1-A2-N1-T1-E1-H1. Phylogenetic analysis revealed that the NSP4 genes of L202 and L234 strains were closer to that of G9P[8]-E2 strains from Japan, suggesting they might share a common ancestor. The findings from this study provide new insights into the genetic characteristics of circulating G9P[8] strains in Sabah, which are important for rotavirus surveillance and potential vaccine development in the region.

Item Type:	Article
Keyword:	Rotavirus Malaysia Whole-genome G9P[8]-E2 G9P[8]-A2 Reassortment
Subjects:	R Medicine > RS Pharmacy and materia medica > RS139-141.9 Pharmacopoeias R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica > RS355-356 Pharmaceutical supplies
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	14 Jan 2025 12:51
Last Modified:	14 Jan 2025 12:51
URI:	https://eprints.ums.edu.my/id/eprint/42583

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