Risk factors,diagnosis, and management of peptic ulcer disease

Murtaza Mustafa and Jayaram Menon and RK.Muiandy and Fredie Robinson and MM.Sein and A.Fariz (2015) Risk factors,diagnosis, and management of peptic ulcer disease. Journal of Dental and Medical Sciences, 14. pp. 1-7. ISSN 2279-0861

Text FULL TEXT.pdf Restricted to Registered users only Download (146kB) | Request a copy

Abstract

For nearly 100 years, scientists and doctors thought that ulcers were caused by stress, spicy food, and alcohol. Treatment was bed rest and antacids, but in 1982 discovery of Helicobacter pylori confirmed its role in in gastric, duodenal ulcers and gastric cancer. Peptic ulcer disease (PUD) is the most common human ailment affecting nearly 50% of world population, with high mortality in gastric cancer. Gastric ulcer had male preponderance; duodenal ulcer was 10 times as common as in women. The causes of PUD include H.pylori infection, non- steroidal anti- inflammatory drugs (NSAIDs), pepsin, smoking, alcohol, bile-acids, steroids, stress and changes in gastric mucin consistency. Other causes include Bechetdisease,Zollinger_Ellisonsyndrome,Crohndisease,livercirrhosis,stomach cancer, coronary heart disease and inflammation of stomach lining or gall bladder. Frequent symptoms include epigastric pain, nausea, flatulence, bloating and heartburn. The currently recommended eradication regimens should have eradication rate of 90% or greater. Triple therapy is consist of PPI,a combination of two antimicrobials such as amoxicillin and clarithromycin.Quardrupletherapy:PPI(sandard dose twice daily)+metronidazole(500 mg 3 times daily)+ tetracycline(500 mg 3 times daily)+bismuth(dose depend on preparation) for 10 days.Prognosis of PUD is excellent if the underlying cause such as H.pylori infection or use of NSAIDs can be addressed.

Item Type:	Article
Keyword:	Peptic ulcer disease (PUD),Riskfactors, Helicobacter pylori infection,NSAIDS
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC705-779 Diseases of the respiratory system R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC581-951 Specialties of internal medicine > RC799-869 Diseases of the digestive system. Gastroenterology
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	14 Jan 2025 12:53
Last Modified:	14 Jan 2025 12:53
URI:	https://eprints.ums.edu.my/id/eprint/42586

Actions (login required)

View Item