Kamsia Budin and Mazlina Mizan and Nur Zaida Zahari and Rohana Tair and Fera Cleophas and Farrah Anis Fazliatul Adnan (2024) Risk-based prioritisation of high-risk antibiotics on aquatic organisms in Malaysia.
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Abstract
Antibiotics are widely used in hospitals, households, agriculture, and veterinary practices, but their residues in aquatic environments pose significant risks to aquatic organisms and human health. Despite their extensive use, research on antibiotic contamination in Malaysia's surface waters is limited. This study aimed to evaluate the effects of antibiotics on aquatic ecosystems by analysing consumption data, excreta and predicted environmental concentrations (PEC) from 2012 to 2016. A risk-based methodology assessed the toxicity of 30 antibiotics, ranking them by their risk quotient (RQ). From 2012 to 2016, Malaysia's most used antibiotics were Amoxicillin, Cloxacillin, and Cefalexin, with Cefalexin showing the highest PEC values. The study found that Amoxicillin, Azithromycin, and Cloxacillin posed significant risks to aquatic organisms like algae, Daphnia, and fish. Amoxicillin had the highest RQ values overall, while Azithromycin was particularly hazardous to algae, and Cloxacillin presented threats to both algae and fish populations. This research highlights the need for further investigation into antibiotic pollution's long-term and indirect effects on aquatic ecosystems. Additionally, studying chronic toxicity at environmentally relevant concentrations is crucial for understanding the broader environmental implications of antibiotic contamination.
| Item Type: | Proceedings |
|---|---|
| Keyword: | Antibiotics, Predicted Environmental Concentration, PEC, Predicted No-Effect Concentration, PNEC, Risk-Quotient, RQ |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology > RM265-267 Antibiotic therapy. Antibiotics S Agriculture > SH Aquaculture. Fisheries. Angling > SH1-691 Aquaculture. Fisheries. Angling > SH20.3-191 Aquaculture |
| Department: | FACULTY > Faculty of Science and Natural Resources |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 17 Mar 2025 11:06 |
| Last Modified: | 17 Mar 2025 11:06 |
| URI: | https://eprints.ums.edu.my/id/eprint/43213 |
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