Ammielle Akim Kerudin and Rodney Petrus Balandong (2024) Molecular markers in ancient DNA studies of mycobacterium tuberculosis complex: tools for tracing pathogen evolution and disease dynamics.
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Abstract
The study of ancient Mycobacterium tuberculosis complex (MTBC) DNA has revolutionized our understanding of the evolution, epidemiology, and historical impact of tuberculosis (TB) on human populations. Molecular markers such as insertion sequences (IS6110, IS1081), large sequence polymorphisms (LSPs), and single nucleotide polymorphisms (SNPs) have emerged as indispensable tools for identifying and characterizing ancient MTBC strains. These markers facilitate the reconstruction of phylogenetic relationships, uncovering the evolutionary history of TB and its coevolution with human populations. Advances in technologies such as next-generation sequencing (NGS), target enrichment, and metagenomics have further enhanced the ability to analyze degraded and low-abundance DNA from archaeological samples. This review examines the key molecular markers used in ancient DNA studies of MTBC and their contributions to understanding the genetic diversity, global spread, and adaptive strategies of TB over millennia.
| Item Type: | Proceedings |
|---|---|
| Keyword: | Tuberculosis, TB, Mycobacterium tuberculosis |
| Subjects: | R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC306-320.5 Tuberculosis T Technology > T Technology (General) > T1-995 Technology (General) |
| Department: | FACULTY > Faculty of Science and Natural Resources |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 19 Mar 2025 14:30 |
| Last Modified: | 19 Mar 2025 14:30 |
| URI: | https://eprints.ums.edu.my/id/eprint/43258 |
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