Biomarkers, isolation methods, and therapeutic implications of breast cancer stem cells

Teoh, Peik Lin and Nurshafiqah Saini (2025) Biomarkers, isolation methods, and therapeutic implications of breast cancer stem cells. Cancer Pathogenesis and Therapy, xxx. pp. 1-10. ISSN 2949-7132

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Abstract

Breast cancer metastasis and relapse remain uncontrollable despite significant advancements in early diagnosis and treatment, resulting in increased mortality. Breast cancer is the most frequently diagnosed cancer in women worldwide and has become the leading cause of cancer-related deaths. Cancer stem cells (CSCs) may play significant roles in tumor initiation, maintenance, invasion, relapse, metastasis, and therapy resistance. Although this small, highly heterogeneous, and restricted population of CSCs has been extensively studied, their cellular and molecular physiology remains unclear. Nonetheless, CSCs have increasingly become an attractive therapeutic target for combating advanced, treatment-resistant cancers. This necessitates the development of effective and reliable methods for their isolation and enrichment. This review provides an overview of the key characteristics of breast cancer stem cells (BCSCs) and illustrates their role in therapeutic resistance. Furthermore, it highlights various mechanisms underlying cancer cell adaptability and therapy-induced resistance across different breast cancer subtypes. The commonly used methods for BCSC isolation and identification are also discussed, as they could facilitate a deeper understanding of tumorigenesis, metastasis, resistance, and relapse, consequently contributing to the development of more effective therapeutic strategies for breast cancer.

Item Type:	Article
Keyword:	Cancer stem cell, Surface marker, Side population, Resistance, Cancer therapy
Subjects:	Q Science > Q Science (General) > Q1-390 Science (General) R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	28 Apr 2025 13:32
Last Modified:	28 Apr 2025 13:32
URI:	https://eprints.ums.edu.my/id/eprint/43586

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