Metabolic fingerprinting of Sabah Ruellia tuberosa plant extracts for the identification of potential anticancer compounds

Jan Renee Stephanie Jiorry (2014) Metabolic fingerprinting of Sabah Ruellia tuberosa plant extracts for the identification of potential anticancer compounds. Masters thesis, Universiti Malaysia Sabah.

	Text 24 PAGES.pdf Download (1MB)
	Text FULLTEXT.pdf Restricted to Registered users only Download (11MB)

Abstract

Ruellia tuberosa, commonly known as Minnie Root or Cracker Plant, is a traditional medicinal plant used for its diuretic, antidiabetic, and antipyretic properties. Recent findings suggest significant anticancer activity, particularly against breast cancer (MCF-7) cells. This study aimed to identify the potential anticancer compounds in Sabah's R. tuberosa through a metabolic fingerprinting approach using gas chromatography-mass spectrometry (GC-MS). A total of 15 compounds were identified in the leaf extract, 10 in the stem, and 10 in the root. Compounds such as squalene, stigmasterol, campesterol, vitamin E, and lupeol were consistently found and highly speculated to contribute to anticancer activity. Chemical databases were built using PCDL software, and the compounds were correlated with MTT assay data. The findings encourage further isolation and functional analysis of these bioactives to validate their cytotoxic effects on MCF-7 cells.

Item Type:	Thesis (Masters)
Keyword:	Ruellia tuberosa, Medicinal plants, Sabah, Anticancer compounds, Breast cancer,
Subjects:	Q Science > QK Botany > QK1-989 Botany > QK900-989 Plant ecology
Department:	INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User:	DG MASNIAH AHMAD -
Date Deposited:	28 Apr 2025 15:52
Last Modified:	28 Apr 2025 15:52
URI:	https://eprints.ums.edu.my/id/eprint/43587

Actions (login required)

View Item