Fatemeh Kianizadegan and Mohammad Rami and Aliakbar Alizadeh and D Maryama Awang Daud (2024) The effect of six weeks of high-intensity interval training with hawthorn extract supplementation on the changes of BAX/Bcl-2 Indices in the hippocampus tissue of aged male Wistar rats. Journal of Isfahan Medical School, 42 (769). pp. 1-11.
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Abstract
Background: Aging is a complex and multifactorial phenomenon characterized by a gradual decrease in physiological functions in various organs. The central nervous system and the hippocampus are significantly affected by the effects of aging, such as apoptosis. The synergistic effects of physical activity and natural antioxidants such as hawthorn to protect brain damage against apoptosis may be the key to inhibiting or reducing the apoptosis of nerve cells in the aging process. Therefore, this study aims to investigate the effect of high-intensity interval training with hawthorn extract supplementation on the changes of BAX/Bcl-2 indices in the hippocampus tissue of aged rats. Methods: In this experimental research, 30 male Wistar field rats 22 months of age were randomly divided into five groups of six, including young, elderly, elderly/exercise, elderly/extract, and elderly/extract/exercise. In the groups that used hawthorn extract, they received 100 mg/kg of the extract by gavage after training sessions. The high-intensity interval training protocol was for six weeks with an intensity of 80-100% of maximum speed. After tissue removal, BAX/Bcl-2 protein levels were measured using the western blot method. One-way ANOVA and Tukey's post hoc test were used to examine the research variables. Findings: The results of the present study showed that aging caused a significant decrease in the Bcl-2 variable and a significant increase in the BAX variable (P = 0.001). Also, the results of this research showed that both highintensity interval training and hawthorn extract consumption caused a consequential advance in Bcl-2 values (respectively, P = 0.031 and P = 0.011) and a significant decrease in BAX protein (P = 0.003 and P = 0.016, respectively). In addition, the results of this research showed that the synergistic effects of high-intensity interval training in the elderly/extract/exercise group caused a significant increase and decrease in Bcl-2 and BAX variables, respectively, compared to the elderly/exercise and elderly/extract groups (P < 0.05). Conclusion: According to the results of this research, it can be stated that the synergy of the beneficial effects of high-intensity intermittent physical activity along with the consumption of hawthorn extract in increasing the Bcl2 variable and decreasing the BAX variable can probably play a consequential role in inhibiting the apoptosis process in the rat hippocampus tissue and can probably be a promising non-pharmacological strategy.
| Item Type: | Article |
|---|---|
| Keyword: | Aging; Apoptosis; Hippocampus; Exercise |
| Subjects: | Q Science > QH Natural history > QH301-705.5 Biology (General) > QH573-671 Cytology Q Science > QP Physiology > QP1-(981) Physiology > QP1-345 General Including influence of the environment |
| Department: | FACULTY > Faculty of Medicine and Health Sciences |
| Depositing User: | ABDULLAH BIN SABUDIN - |
| Date Deposited: | 02 May 2025 11:19 |
| Last Modified: | 02 May 2025 11:19 |
| URI: | https://eprints.ums.edu.my/id/eprint/43716 |
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