Rolinus Paulous and Zuraini Zakaria and Julianah Awang and Takashi Kamada and Charles S. Vairappan (2022) Antifungal diterpene from Rhizome of wild bornean ginger, Hornstedtia havilandii (Zingiberaceae). Biochemical Systematics and Ecology, 105. pp. 1-4. ISSN 0305-1978
![[img]](https://eprints.ums.edu.my/style/images/fileicons/text.png) |
Text
FULL TEXT.pdf Restricted to Registered users only Download (906kB) |
Abstract
Hornstedtia havilandii (K. Schum.) belongs to the ginger (Zingiberaceae) family and is one of the nine reported species of Hornstedtia in Borneo. It is widely used as an important resource in traditional healing and cultural practices by the tribal communities. Rhizome of H. havilandii was extracted in ethanol and its biologically active antifungal metabolite was isolated via bioassay-guided separation technique. Isolated compound was subjected to spectroscopy measurements and the structure was elucidated as (E)-labda-8(17),12-diene-15,16-dial (1). Although 1 was identified as a previously published compound, we were able to differentiate and assign the chemical shift values for two overlapping carbons; C-4 and C-18 via Gaussian processing of the 13C-NMR data, and consequent 2D NMR assignments. The antifungal activities were seen against crustacean pathogenic fungal strains Lagenidium thermophilum, Haliphthoros sabahensis, and Haliphthoros milfordensis as MIC value of <82.78 μM (25 μg/mL) while Fusarium solani and Fusarium oxysporum required <165.56 μM (50 μg/mL). In addition, this is the first record of H. havilandii that produces labdane type diterpene. Data revealed here could be used as an important chemotaxonomic marker for this genus.
| Item Type: | Article |
|---|---|
| Keyword: | Zingiberaceae, Hornstedtia havilandii (K. Schum), Labdane-type diterpene, Antifungal, Chemotaxonomy |
| Subjects: | Q Science > QK Botany > QK1-989 Botany R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) |
| Department: | INSTITUTE > Institute for Tropical Biology and Conservation |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 10 Jun 2025 11:45 |
| Last Modified: | 10 Jun 2025 11:45 |
| URI: | https://eprints.ums.edu.my/id/eprint/43999 |
Actions (login required)
 |
View Item |