The effects of ketone bodies and ketogenesis on the PI3K/AKT/mTOR signaling pathway: A systematic review

Azlinah Matawali and Jia Wen Yeap and Shaida Fariza Sulaiman and Mei Lan Tan (2025) The effects of ketone bodies and ketogenesis on the PI3K/AKT/mTOR signaling pathway: A systematic review. Nutrition Research, 139. pp. 1-33.

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Abstract

Ketogenesis and the PI3K/AKT/mTOR pathway are linked to metabolic imbalance and dis- ease progression. While ketone metabolism and mTOR inhibition are mechanistically con- nected, their functional relationship across disease models remains unclear. Although ke- togenesis can be induced by ketone ingestion, ketogenic diet, or fasting, their individual effects on this pathway require further clarification. This study systematically reviews the relationship between ketogenesis and PI3K/AKT/mTOR signaling, following PRISMA guide- lines across 3 databases. Eligible studies that met the selection criteria were evaluated using

Item Type:	Article
Keyword:	PI3K/AKT/mTOR Ketogenesis Ketogenic diet Ketone bodies
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry > RC346-429 Neurology. Diseases of the nervous system Including speech disorders R Medicine > RM Therapeutics. Pharmacology > RM1-950 Therapeutics. Pharmacology > RM214-258 Diet therapy. Dietary cookbooks
Department:	CENTRE > Preparation Centre for Science and Technology
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	20 Jun 2025 16:17
Last Modified:	20 Jun 2025 16:17
URI:	https://eprints.ums.edu.my/id/eprint/44235

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