Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease

Chee wah yuen and Mardani Abdul Halim and Vikneswaran murugaiyah and Nazalan Najimudin and Ghows Azzam (2020) Tocotrienol decreases ß-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease. pp. 1-15.

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Abstract

Alzheimer’s disease (AD) is a neurological disease caused by the accumulation of extracellular senile plaques consisting of β-amyloid peptide (Aβ) in the brain. A transgenic Caenorhabditis elegans which demonstrated paralysis due to the expression of human beta amyloid Aβ42 gene was used to study the anti-paralysis effect of mixed tocotrienols. The content of the mixed tocotrienols were 12.1% α-, 2.7% β-, 18.6% γ-, and 8.1% δ-tocotrienols. Mixed tocotrienols significantly delayed the Aβ-induced paralysis in the transgenic nematode and exhibited anti-oxidant properties towards Aβ-generated oxidative stress. The mixture also presented potent inhibitory activities against Aβ aggregation with an IC50 value of 600 ng/ml. It is concluded that mixed tocotrienols could potentially serve as a new therapeutic candidate for AD.

Item Type:	Article
Keyword:	Alzheimer’s disease, beta amyloid, C. elegans, tocotrienol, tocotrienol
Subjects:	Q Science > QP Physiology > QP1-(981) Physiology > QP501-801 Animal biochemistry R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry
Department:	INSTITUTE > Biotechnology Research Institute (BRI)
Depositing User:	ABDULLAH BIN SABUDIN -
Date Deposited:	03 Jul 2025 16:18
Last Modified:	03 Jul 2025 16:18
URI:	https://eprints.ums.edu.my/id/eprint/44355

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