The efficacy and safety of dapagliflozin in pediatric heart failure: Interpreting causality in clinical outcomes

Kaiyuan Cena and Fatimah Ahmedy and Mexmollen Marcus and Mohd Fadzli Shukor (2025) The efficacy and safety of dapagliflozin in pediatric heart failure: Interpreting causality in clinical outcomes. International Journal of Cardiology, 437. p. 1. ISSN 0167-5273

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Abstract

We read with great interest the report by Kumar et al. [1], which describes functional and echocardiographic improvements in pediatric heart failure after initiating dapagliflozin. These encouraging findings offer valuable insights; however, attributing the clinical benefits solely to the drug may be premature given certain limitations in study design and interpretation. In observational analyses—especially in cohorts with diverse characteristics—multiple factors can contribute to the outcomes observed.

Item Type:	Article
Keyword:	Pediatric, Heart failureQ
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General) R Medicine > RJ Pediatrics > RJ1-570 Pediatrics > RJ370-550 Diseases of children and adolescents
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	15 Jul 2025 15:34
Last Modified:	15 Jul 2025 15:34
URI:	https://eprints.ums.edu.my/id/eprint/44461

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