AB-470. A double positive antibody: A case report on Guillain-Barré syndrome with positive anti-GT1a and anti-GQ1b ganglioside antibody

Alvin Oliver Payus and Tan, Hui Jan and Lee, Aik Kheng and Tan, Juen Kiem and Rabani Remli (2025) AB-470. A double positive antibody: A case report on Guillain-Barré syndrome with positive anti-GT1a and anti-GQ1b ganglioside antibody. Clinical Neurophysiology, 172. S64-S64.

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Abstract

Guillain-Barré syndrome (GBS) is an immune mediated peripheral polyneuropathy characterised by acute onset ascending symmetrical muscle weakness with or without bulbar involvement. Recently, anti-ganglioside antibodies played a major role in the pathophysiology and often closely related to the clinical phenotypes and specific manifestations of the condition. The presence of anti-GQ1b antibody is associated with ophthalmoplegia and ataxia in patient with Miller Fischer variant. This is because GQ1b gangliosides are densely localized in the paranodal regions of the oculomotor nerves and in the subpopulation of large neurons in the dorsal root ganglia. GT1a gangliosides on the other hand have been abundantly found in glossopharyngeal and vagal nerves. Therefore, monospecific anti-GT1a antibody which does not cross-react with anti-GQ1b was found to be highly related with bulbar palsy. However, anti-GQ1b and anti GT1a antibodies that cross-reactive to each other is not often reported. Here, we report a case of a case with predominant cranial nerves and sensory involvement and relatively sparring the motor component.

Item Type:	Article
Keyword:	Guillain-Barré syndrome, positive anti-GT1a, anti-GQ1b ganglioside antibody
Subjects:	R Medicine > RB Pathology > RB1-214 Pathology > RB127-150 Manifestations of disease R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	SITI AZIZAH BINTI IDRIS -
Date Deposited:	15 Jul 2025 16:25
Last Modified:	15 Jul 2025 16:25
URI:	https://eprints.ums.edu.my/id/eprint/44499

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