Effects of methiopropamine on cognitive function and monoaminergic systems in mice

Mohd Khairulanwar Bunaim and Nor syafinaz Yaakob and Hanafi Ahmad Damanhuri and hui-Yin Yow and Fadhlullah Zuhair Japar sidik and Norizal Mohd Noor and Norazrina azmi (2025) Effects of methiopropamine on cognitive function and monoaminergic systems in mice. Drug and ChemiCal ToxiCology, 48. pp. 1-11. ISSN 0148-0545

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Abstract

Methiopropamine (MPa), a novel psychoactive substance (NPs) similar to methamphetamine (Meth), warrants investigation into its neurotoxic effects on cognitive function and behaviors due to limited existing research. therefore, this study aimed to explore the effects of MPa on several behavioral parameters in mice, brain levels of monoamine neurotransmitters, and p-eRK1/2 expression. Mice were randomly divided into four groups (n = 10) which received daily intraperitoneal injections of either saline, 1 or 3 mg/kg of MPa, or 1 mg/kg of Meth for 7 days. the novel object recognition test (NORt) revealed a significant decline in recognition memory, particularly evident at a dose of 3 mg/kg of MPa, similar to Meth at 1 mg/kg, observed 24 h post-withdrawal. MPa at 3 mg/kg also impaired working and reference memory performance in the 8-arm radial maze (8-aRM) test and exhibited an anxiolytic effect in the open field test (OFt). these cognitive impairments were accompanied by decreased dopaminergic parameters and p-eRK1/2 expression within the prefrontal cortex (PFc). this further suggests that MPa neurotoxicity is targeted at the dopaminergic transmission in the PFc. in conclusion, MPa consumption is associated with memory impairment, which is attributable to dopaminergic deficits and reduced p-eRK1/2 activities in the PFc.

Item Type:	Article
Keyword:	Methiopropamine, new psychoactive substances (NPs), memory impairment, dopaminergic transmission, neurotoxicity
Subjects:	Q Science > QP Physiology > QP1-(981) Physiology > QP351-495 Neurophysiology and neuropsychology R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry > RC346-429 Neurology. Diseases of the nervous system Including speech disorders
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	JUNAINE JASNI -
Date Deposited:	29 Jul 2025 11:57
Last Modified:	29 Jul 2025 11:57
URI:	https://eprints.ums.edu.my/id/eprint/44675

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