Cytotoxicity of physalis minima Linn (Solanaceae) fruit against HCT116 And HT29 colorectal cancer cell lines

Wei Lun Ng and Jen Kit Tan and Charles Gnanaraj and Muhammad Dawood Shah and Nurshamimi Nor Rashid and Iskandar Abdullah and Yoong Soon Yong (2024) Cytotoxicity of physalis minima Linn (Solanaceae) fruit against HCT116 And HT29 colorectal cancer cell lines. Natural Product Research: Formerly Natural Product Letters. pp. 1-6. ISSN 1478-6419

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Abstract

The pantropical Physalis minima are traditionally used for the prevention and treatment of various illnesses, diseases, and cancers. While most earlier studies on the species have focused on the phytochemistry of the leaf and stem extracts, recent studies have indicated that its fruit may contain bioactive compounds of medical interest. In this study, we investigated the cytotoxicity of extracts from the fruit of P. minima against colorectal cancer cell lines and revealed its phytochemical profile via high-resolution tandem mass spectrometry analysis. Following a 24-h treatment with the fruit extract, cytoplasm shrinkage and nucleus condensation were observed in the colorectal cancer cell lines HCT116 and HT29, indicating the induction of programmed cell death. Phytochemically, 71 putative metabolites were identified. Some of these metabolites have been reported to inhibit cancers to varying degrees, further supporting the correlation of the putative metabolites with the cytotoxicity against colorectal cancer cells demonstrated in this study.

Item Type:	Article
Keyword:	Physalis Minima Linn, Bioactive Metabolite, Gooseberry, High-resolution Tandem Mass Spectrometry, Programmed Cell Death
Subjects:	P Language and Literature > PZ(1)-90 Fiction and juvenile belles lettres > PZ(1)-90 Fiction and juvenile belles lettres > PZ5-90 Juvenile belles lettres R Medicine > RS Pharmacy and materia medica > RS153-441 Materia medica > RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Department:	INSTITUTE > Borneo Marine Research Institute
Depositing User:	JUNAINE JASNI -
Date Deposited:	13 Aug 2025 11:16
Last Modified:	13 Aug 2025 11:16
URI:	https://eprints.ums.edu.my/id/eprint/44775

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