Interleukin-6 level in vivo and in vitro Anti-Inflammatory and Anti-Pyretic evaluation of Aloe Vera ethanolic extract in Sprague Dawley

Solihati and Mohd Hijaz Mohd Sani and Fong Siat Yee Alison and Hartanto Mulyo (2025) Interleukin-6 level in vivo and in vitro Anti-Inflammatory and Anti-Pyretic evaluation of Aloe Vera ethanolic extract in Sprague Dawley. Journal of Neonatal Surgery, 14 (215). pp. 707-713.

Text FULLTEXT.pdf Restricted to Registered users only Download (1MB) | Request a copy

Abstract

Aloe vera has been extensively used in cosmetic applications. Aloe vera has anti-inflammatory, antipyretic and antioxidant effects. Objective: to correlate the anti-inflammatory & antipyretic effect of Aloe vera ethanolic extract (AVEE) in vivo and in vitro models in rats in the interleukin-6 level. Methods: a true experimental design with randomized approach included 25 male Sprague-Dawley rats. Separation and purification of each secondary metabolite of AVEE by phytochemical screening at the University of Indonesia laboratory. Rat paw edema was induced with cotton pellet-induced granuloma formation and IL-6 level. Efficacy of aloe vera was analyzed using ANOVA by SPSS v.27.0. the p-value for statistical significance was defined as p<0.01 Results: AVEE effective reduced granuloma tissue formation and protected granuloma through inflammation induced by cotton pellets and histological examination at 200 mg/kg BW. The effective concentration that effect IL6 concentration is 200 mg/kg BW AVEE and statistically significant(P<0.01). Conclusion: Aloe Vera Ethanolic Extract (AVEE) has anti-inflammatory and antipyretic activity in rats, although no significant to activity antipyretic in rats.

Item Type:	Article
Keyword:	Aloe Vera extract, cotton pellet-induced, granuloma formation, Interleukin-6
Subjects:	Q Science > QK Botany > QK1-989 Botany > QK1-474.5 General Including geographical distribution R Medicine > RL Dermatology > RL1-803 Dermatology
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	JUNAINE JASNI -
Date Deposited:	22 Aug 2025 10:28
Last Modified:	22 Aug 2025 10:28
URI:	https://eprints.ums.edu.my/id/eprint/45040

Actions (login required)

View Item