The miRNA landscape of leukemia – cellular actions to therapy through molecular mechanisms

Kang Zi Khor and Adam Azlan and Julia Joseph and Jeyrubini Ramesh and Maheswaran Solayappan and Yee Yik Mot and Mohamed Saleem and Narazah Mohd Yusoff and Emmanuel Jairaj Moses (2025) The miRNA landscape of leukemia – cellular actions to therapy through molecular mechanisms. Cell Biochemistry and Biophysics, 83. pp. 1-23. ISSN 1085-9195

Text FULLTEXT.pdf Restricted to Registered users only Download (1MB) | Request a copy

Abstract

The Nobel Prize in Physiology and Medicine awarded to Victor Ambros and Gary Rukum for their work in microRNA (miRNA) emphasized the important role that miRNA plays in biology. These conserved small noncoding RNA molecules play pivotal role especially in the post transcriptional stage of gene regulation, affecting various key cellular processes by interacting with target genes complement to the conserved miRNA seed sequence. Over the years miRNA was implicated in all manners of diseases with abnormal gene regulation especially in cancer. In leukemia, miRNA dysregulation could lead to aberrant cellular processes. These include but are not limited to leukemic development, survival and drug resistance. miRNA also have important clinical implications as differential miRNA abundance could contribute towards leukemogenesis. This is especially useful in the diagnosis and prognosis of leukemia. This review aims to explore and highlight the role of miRNAs in leukemia development, progression and to discuss miRNA involvement towards leukemic resistance to therapy.

Item Type:	Article
Keyword:	MicroRNA, Myeloid leukemia, Lymphoid leukemia, Cancer, Disease
Subjects:	Q Science > QP Physiology > QP1-(981) Physiology > QP1-345 General Including influence of the environment R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	JUNAINE JASNI -
Date Deposited:	02 Sep 2025 15:50
Last Modified:	02 Sep 2025 15:50
URI:	https://eprints.ums.edu.my/id/eprint/45091

Actions (login required)

View Item