A case series of isolated sixth nerve palsy lesson from the literature and three case studies

Chan, Shi Ying and Yap, Jin Yi and Lim, Yi Wen (2025) A case series of isolated sixth nerve palsy lesson from the literature and three case studies. SN Comprehensive Clinical Medicine, 7 (319). pp. 1-5.

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Abstract

Isolated sixth nerve (CN VI) palsy can result from a variety of aetiologies. Comprehensive clinical evaluation and appropriate neuroimaging are essential for accurate diagnosis and prompt management. Case Presentation Patient 1, a 55-year-old male, with underlying diabetes and hypertension, presented with sudden onset of diplopia and was diagnosed with an ischemic aetiology. Patient 2, a 57-year-old male, experienced a 2-week history of binocular horizontal diplopia, accompanied by headache and constitutional symptoms. Imaging and histopathological examination revealed aggressive nasopharyngeal carcinoma. Patient 3, a previously healthy 31-year-old male, was diagnosed with Miller-Fisher syndrome based on clinical features and cerebrospinal fluid analysis. Two patients showed complete recovery, while one patient had partial recovery after 6 months. Conclusion While this case series may not present a novel mechanism of CN VI palsy, it provides a practical, real-world illustration of its varied presentations across different age groups and underlying pathologies. The cases underscore the importance of considering patient demographics, clinical context, and imaging findings in guiding diagnosis and management.

Item Type:	Article
Keyword:	Clinical presentation, Diplopia, Ischemic aetiology, Neuroimaging, Sixth cranial nerve palsy
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine > RC321-571 Neurosciences. Biological psychiatry. Neuropsychiatry > RC346-429 Neurology. Diseases of the nervous system Including speech disorders
Department:	FACULTY > Faculty of Medicine and Health Sciences
Depositing User:	DG MASNIAH AHMAD -
Date Deposited:	31 Oct 2025 17:19
Last Modified:	31 Oct 2025 17:19
URI:	https://eprints.ums.edu.my/id/eprint/45595

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