Tan, Wei Fei (2008) Anti-mycobacterium property of anacardium occidentale. Universiti Malaysia Sabah. (Unpublished)
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Abstract
Tuberculosis (TB) disease is caused by Mycobacterium tuberculosis. Despite the development of anti-TB drugs, but still unable to treat persistent TB, there were 3 million deaths in the 1990s due to this disease. Therefore, TB remains a leading cause of mortality worldwide into the 21st century. In this study, leave extracts were obtained and subjected to agar-diffusion screening systems with acetate and glucose utilization of H8000 Mycobacterium smegmatis mc²155 targeted on glyoxylate cycle and two component signal transduction. The screening result showed that all the extract fractions showed inhibition against glyoxylate cycle with the n-butanol showed the most promising potential to be develop as anti-persistent drugs for treating persistent mycobacteria with cytotoxic effect. In two-component screening system, the dichloromethane extract and aqueous extract showed promising activity targeting two-component system.
| Item Type: | Academic Exercise |
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| Keyword: | Mycobacterium tuberculosis, Tuberculosis disease, extract fraction, dichloromethane extract, aqueous extract, anti-TB drug |
| Subjects: | Q Science > QR Microbiology |
| Department: | SCHOOL > School of Science and Technology |
| Depositing User: | SITI AZIZAH BINTI IDRIS - |
| Date Deposited: | 14 Mar 2014 12:05 |
| Last Modified: | 12 Oct 2017 14:20 |
| URI: | https://eprints.ums.edu.my/id/eprint/8497 |
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