Comparative study of the oxidative and physical stability of liposomal and nanoliposomal polyunsaturated fatty acids prepared with conventional and Mozafari method

Babak Rasti and S Jinap and M. R. Mozafari and Yazid M Abd Manap (2012) Comparative study of the oxidative and physical stability of liposomal and nanoliposomal polyunsaturated fatty acids prepared with conventional and Mozafari method. Food Chemistry, 135 (4). pp. 2761-2770. ISSN 0308-8146

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Abstract

The relative oxidative stability of freshly prepared and stored liposomal and nanoliposomal systems of docosahexaenoic acid (DHA, 22:6 n−3) and eicosapentaenoic acid (EPA, 20:5 n−3) were investigated. The effects of organic solvents on the oxidative stability of liposomal polyunsaturated fatty acids (PUFAs) produced by two methods, the Bangham thin-film hydration (conventional rotary evaporation method and using organic solvents) and Mozafari (direct hydration and without using organic solvents) methods, were compared. The highest physicochemical stability was observed in PUFA liposomes prepared by the Mozafari method, followed by conventional liposomes and bulk PUFAs. There was no significant change in physicochemical stability during 10 months of cold storage (4 °C) in the dark. Moreover, the comparison between liposomes (>200 nm) and nanoliposomes (50–200 nm) revealed that the surface charge, physical stability and oxidative stability of liposomal PUFAs increased as the size of the liposomes decreased. The differences in the oxidative stability of PUFAs may be due to the protective effects of aqueous systems, which indicate the advantage of using non-organic solvent (water and CO2) techniques in liposome manufacturing.

Item Type: Article
Keyword: Long-chain polyunsaturated fatty acids, DHA, EPA, Nano-encapsulation, Nanoliposomes, Oxidative stability, Phospholipids
Subjects: T Technology > TX Home economics > TX1-1110 Home economics > TX341-641 Nutrition. Foods and food supply
Department: FACULTY > Faculty of Food Science and Nutrition
Depositing User: ADMIN ADMIN
Date Deposited: 11 May 2016 14:08
Last Modified: 22 Aug 2021 19:15
URI: https://eprints.ums.edu.my/id/eprint/12571

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